Retinoid Synthesis and Manufacturing
Retinoids are chemical compounds that are derived from vitamin A, and play a role in diverse biological process such as the regulation of epithelial cell growth, immune function, the activation of tumor suppressor genes, and vision.
If you have a retinoid project that needs development and manufacturing, request a free project evaluation today.
Multi-kilo Retinoid Manufacturing Process
The chemists at Cedarburg Hauser Pharmaceuticals have developed and patented a unique process that produces multi-kilogram quantities of Fenretinide – a retinoid currently being developed to treat macular degeneration as well as a variety of different types of cancer.
John Cabaj and Jeff Hutchison, Senior Scientists at Cedarburg Hauser Pharmaceuticals, patented this process in 2008. The full patent can be reviewed on the United States Patent and Trademark Office website by clicking on the listing below.
We have developed methods for handling and storing this light-sensitive compound on large scale, and have the expertise to make related retinoids for research or clinical trials.
“Preparation of Amides of Retinoic Acid via Mixed Anhydride and Mixed Carbonate Intermediates.” Cabaj, Hutchison
U. S. Patent 7,321,064, (January 2008)
Processes for preparing amides of retinoic acid are disclosed. Intermediates useful in the preparation of amides of retinoic acid are also disclosed. In one version of the invention, fenretinide is produced via activation of retinoic acid (tretinoin) via its corresponding mixed anhydride or mixed carbonate followed by reaction of the activated intermediate with 4-aminophenol. Other amides of retinoic acid and isomers of retinoic acid, such as the 9-cis-form or 13-cis-form can also be made by this invention.
Retinoid Synthesis Expertise
In addition to the example demonstrated above, our chemists have also carried out the synthesis of Acitretin, a retinoid used to treat psoriasis. Cedarburg Hauser Pharmaceuticals is an experienced, contract development and manufacturing company that can help you both design and develop scalable chemistry for the synthesis of your retinoid-based drug or drug candidate. Our experience in process validation, scale-up and manufacturing allows us to carry our process into kilogram and ultimately commercial scale production.
Tell us about your project
If you need a company that has experience and proven success in the area of retinoid synthesis, development and manufacturing, you can feel confident in choosing Cedarburg Hauser Pharmaceuticals. We want to learn more about your project and explore how we can use our experience and expertise in retinoid synthesis and manufacturing to help you achieve the successful outcome you are looking for.